F. M. Heydenreich

This study identifies membrane phosphoinositides as regulators of GPCR-arrestin complex dynamics, showing they stabilize complexes and enable temporal control of receptor signaling and recycling.

The paper integrates residue-level pharmacology data with structural contact data to uncover allosteric networks that govern ligand efficacy and potency in GPCRs.

The paper shows that the vasopressin V2 receptor activates multiple G proteins and that its signaling can be biased by ligand structure.

This study identifies chemotype-specific biased signaling in cannabinoid receptors by analyzing ligand-induced signaling cascades.

This paper demonstrates the functional solubilisation of the β2-adrenoceptor using DIBMA, showing improved thermal stability compared to detergent-based methods.