MAIT cells are minimally responsive to Mycobacterium tuberculosis within granulomas, but are functionally impaired by SIV in a macaque model of SIV and Mtb co-infection
A. L. Ellis, A. J. Balgeman, E. C. Larson, M. Rodgers, C. Ameel, T. Baranowski, P. Maiello, J. Juno, C. Scanga, S. L. O'Connor
This study examines MAIT cell function in a macaque model of SIV and Mtb co-infection, finding minimal Mtb responsiveness within granulomas and impaired TNF secretion during co-infection.
bioRxiv · Jan 7, 2020 · PreprintImmunology