Author

M. Rodgers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 7 Approach:experimental assay· 6 Organism:non-human primate· 6 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

P. Maiello· 6 shared A. J. Balgeman· 3 shared C. Ameel· 3 shared C. Scanga· 3 shared E. C. Larson· 3 shared H. J. Borish· 3 shared J. L. Flynn· 3 shared P. L. Lin· 3 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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6 shared papersImmunology

P. Maiello

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

CD4+ T cells are homeostatic regulators during Mtb reinfection

J. Bromley, S. K. C. Ganchua, S. K. Nyquist, P. Maiello, M. Chao, H. J. Borish, M. Rodgers, J. Tomko, K. Kracinovsky, D. Mugahid, S. N. Nguyen, D. Wang, J. M. Rosenberg, E. C. Klein, H. P. Gideon, , J. L. Flynn

The paper shows that CD4+ T cells reduce inflammation and disease severity during Mtb reinfection by reprogramming CD8+ T cells and innate immune cells.

bioRxiv · Dec 20, 2023 · PreprintImmunology

A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques

A. A. Smith, H. Su, J. Wallach, Y. Liu, P. Maiello, H. J. Borish, C. Winchell, A. W. Simonson, P. L. Lin, M. Rodgers, D. J. Filmore, J. Sakal, K. Lin, V. Vinette, D. Schnappinger, , J. L. Flynn

This study develops a 'suicide' BCG strain that is safely eliminated in immunocompromised hosts but induces stronger immune responses and better protection against Mtb in macaques.

bioRxiv · Nov 22, 2023 · PreprintImmunology

Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model

X. Wang, H. Su, J. B. Wallach, J. C. Wagner, B. J. Braunecker, M. Gardner, K. M. Guinn, T. Klevorn, K. Lin, Y. J. Liu, Y. Liu, D. Mugahid, M. Rodgers, J. Sixsmith, S. Wakabayashi, , D. Schnappinger

This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.

bioRxiv · Nov 19, 2023 · PreprintMicrobiology

The dominance of coinfecting parasites' indirect effects on host traits

D. I. Bolnick, S. Arruda, C. Polania, L. Simonse, A. A. Padhiar, A. Roth, M. Rodgers

This paper investigates how indirect genetic effects (IGEs) from coinfecting parasites influence host traits and shows that dominance of these effects can alter parasite evolution.

bioRxiv · Feb 12, 2023 · PreprintEvolutionary Biology

Host Immunity to Mycobacterium tuberculosis Infection is Similar in Simian Immunodeficiency Virus (SIV)-infected, Antiretroviral Therapy-treated and SIV-naïve Juvenile Macaques

E. C. Larson, A. L. Ellis-Connell, M. Rodgers, A. K. Gubernat, J. L. Gleim, R. V. Moriarty, A. J. Balgeman, Y. K. Menezes, C. Ameel, D. J. Filmore, S. M. Pergalske, J. A. Juno, P. Maiello, A. G. White, H. J. Borish, , C. A. Scanga

This study compares host immunity to Mycobacterium tuberculosis in SIV-infected, ART-treated and SIV-naïve juvenile macaques, finding similar TB progression and T cell responses.

bioRxiv · Dec 14, 2022 · PreprintImmunology

Spontaneous control of SIV replication does not prevent immune dysregulation and bacterial dissemination in animals co-infected with M. tuberculosis

R. V. Moriarty, M. Rodgers, A. Ellis-Connell, A. J. Balgeman, E. C. Larson, F. Hopkins, M. R. Chase, P. Maiello, S. Fortune, C. A. Scanga, S. L. O'Connor

This study shows that SIV+ animals, regardless of viral control, have higher Mtb burden and dysregulated immune responses, leading to increased bacterial dissemination.

bioRxiv · May 10, 2021 · PreprintMicrobiology

MAIT cells are minimally responsive to Mycobacterium tuberculosis within granulomas, but are functionally impaired by SIV in a macaque model of SIV and Mtb co-infection

A. L. Ellis, A. J. Balgeman, E. C. Larson, M. Rodgers, C. Ameel, T. Baranowski, P. Maiello, J. Juno, C. Scanga, S. L. O'Connor

This study examines MAIT cell function in a macaque model of SIV and Mtb co-infection, finding minimal Mtb responsiveness within granulomas and impaired TNF secretion during co-infection.

bioRxiv · Jan 7, 2020 · PreprintImmunology

Pre-existing SIV Infection Increases Susceptibility to Tuberculosis in Mauritian Cynomolgus Macaques

M. Rodgers, C. Ameel, A. Ellis-Connell, A. Balgeman, P. Maiello, G. Barry, T. Friedrich, E. Klein, S. O'Connor, C. Scanga

This study shows that pre-existing SIV infection in macaques increases susceptibility to tuberculosis by impairing immune control of M.tb.

bioRxiv · Jul 3, 2018Immunology