E. C. Larson

Transiently boosting Vγ9+Vδ2+ γδ T cells early in Mtb coinfection of SIV-infected juvenile macaques does not improve Mtb host resistance.

Intravenous BCG induces a more potent airway and lung immune response than intradermal BCG in SIV-infected macaques

This study compares intravenous and intradermal BCG vaccination in SIV-infected macaques, finding IV BCG induces stronger airway and lung immune responses, including TRM cells and polyfunctional T cells.

Host Immunity to Mycobacterium tuberculosis Infection is Similar in Simian Immunodeficiency Virus (SIV)-infected, Antiretroviral Therapy-treated and SIV-naïve Juvenile Macaques

This study compares host immunity to Mycobacterium tuberculosis in SIV-infected, ART-treated and SIV-naïve juvenile macaques, finding similar TB progression and T cell responses.

Spontaneous control of SIV replication does not prevent immune dysregulation and bacterial dissemination in animals co-infected with M. tuberculosis

This study shows that SIV+ animals, regardless of viral control, have higher Mtb burden and dysregulated immune responses, leading to increased bacterial dissemination.

HIV-1 provirus transcription and translation in macrophages differs from macrophages containing pre-integrated cDNA complexes and requires E2F transcriptional programs

The paper compares HIV-1 transcription from pre-integrated cDNA and integrated provirus in macrophages using scRNA-seq, finding that provirus transcription correlates with viral protein production and E2F transcriptional programs.

MAIT cells are minimally responsive to Mycobacterium tuberculosis within granulomas, but are functionally impaired by SIV in a macaque model of SIV and Mtb co-infection

This study examines MAIT cell function in a macaque model of SIV and Mtb co-infection, finding minimal Mtb responsiveness within granulomas and impaired TNF secretion during co-infection.