In vitro evolution predicts emerging CoV-2 mutations with high affinity for ACE2 and cross-species binding
N. Bate, C. G. Savva, P. C. Moody…·N. Brindle
The paper uses in vitro evolution to identify CoV-2 mutations that enhance ACE2 binding and cross-species transmission, finding mutations like Q498H and Q498R/N501Y that are emerging in variants like Omicron.