Spatiotemporal profiling defines persistence and resistance dynamics during targeted treatment of melanoma
J. C. Rubinstein, S. Domanskyi, T. B. Sheridan, B. Sanderson, S. Park, J. Kaster, H. Li, O. Anczukow, M. Herlyn, J. H. Chuang
This study uses spatial transcriptomics and deep learning to analyze melanoma treatment resistance, identifying persister states and resistance mechanisms with spatiotemporal resolution.
bioRxiv · Feb 2, 2024Cancer Biology