S. Park

Genetic basis of state-dependent courtship sounds in inbred mice

The paper investigates genetic contributions to courtship sound patterns in mice, finding strain-specific differences in appetitive but not consummatory behaviors.

A stabilized MERS-CoV spike ferritin nanoparticle vaccine elicits robust and protective neutralizing antibody responses

This paper develops a stabilized MERS-CoV spike ferritin nanoparticle vaccine that elicits strong neutralizing antibodies in mice and non-human primates, providing protection against MERS-CoV infection.

The effect of circulating neutralizing antibodies on the replication of SARS-CoV-2 variants following post-vaccination infections.

This study examines how pre-existing neutralizing antibodies affect viral shedding in post-vaccination SARS-CoV-2 infections, finding that higher titers reduce viral load and duration but are less effective against Omicron variants.

Experimental evolution of Escherichia coli on semi-dry silver, copper, stainless steel, and glass surfaces

This study shows Escherichia coli evolves increased tolerance to copper and silver surfaces without enhanced metal ion resistance or mutation accumulation, suggesting passive metal restriction mechanisms are favored over active efflux.

Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure

This paper develops SIRPα-expressing extracellular vesicles from engineered stem cells to treat acute liver failure by resolving necroptosis and promoting liver regeneration, showing reduced liver damage and improved survival in models.

Dimerization activates the Inversin complex in C. elegans

The paper shows that dimerization activates the Inversin complex in C. elegans, with optogenetic stimulation and genetic studies supporting this mechanism.

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

This study shows DKK2 is required for colon cancer metastasis by generating cancer cells with Paneth cell properties through HNF4A regulation.

Vesicle-mediated mitochondrial clearance underlies an actionable metabolic vulnerability in triple-negative breast cancer

The paper identifies a metabolic vulnerability in triple-negative breast cancer through sphingolipid metabolism, showing that targeting this pathway with eliglustat reduces tumor growth and improves survival.

Enhanced mucosal B- and T-cell responses against SARS-CoV-2 after heterologous intramuscular mRNA prime/intranasal protein boost vaccination with a combination adjuvant.

This study shows that combining intramuscular mRNA priming with intranasal protein boosting using a combination adjuvant enhances mucosal B- and T-cell responses against SARS-CoV-2 compared to other vaccination regimens.

The occurrence of Aerococcus urinaeequi and non-aureus Staphylococci in raw milk negatively correlates with Escherichia coli clinical mastitis

This study identifies specific bacterial species in raw milk that negatively correlate with E. coli clinical mastitis in dairy cows, suggesting their potential role in preventing infection.

Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as novel inhibitor for ELF3-MED23 Interaction

This study synthesizes and evaluates chalcone and pyrazoline derivatives as ELF3-MED23 PPI inhibitors, showing compound 10 effectively reduces HER2 levels and induces apoptosis in HER2-positive gastric cancer cells.

The Early Dodder Gets the Host: Decoding the Coiling Patterns of Cuscuta campestris with Automated Image Processing

This study uses automated image processing to analyze coiling patterns of Cuscuta campestris and finds that coiling efficacy varies with inoculation time of day.

In-situ microscopy-assisted meniscus-guided coating for highly sensitive reduced graphene oxide-based nanocomposite biosensor

The paper develops a meniscus-guided coating technique using in-situ microscopy and CFD modeling to create high-performance rGO-based biosensors with picomolar detection limits.

Spatiotemporal profiling defines persistence and resistance dynamics during targeted treatment of melanoma

This study uses spatial transcriptomics and deep learning to analyze melanoma treatment resistance, identifying persister states and resistance mechanisms with spatiotemporal resolution.

Development of Ingenui-T, a Novel Vein-to-Vein Solution for Rapid Autologous CAR T-Cell Manufacturing Starting From Whole Blood, for the Treatment of Autoimmune Diseases

This paper introduces Ingenui-T, a method for rapid CAR T-cell manufacturing from whole blood, showing comparable or better functional activity than conventional methods.

Collagen mineralization decreases NK cell-mediated cytotoxicity of breast cancer cells via increased glycocalyx thickness

This study shows that collagen mineralization increases NK cell resistance in breast cancer by thickening the tumor cell glycocalyx through enhanced sialylation.

Discovery of Highly Active Kynureninases for Cancer Immunotherapy through Protein Language Model

The paper identifies and validates four kynureninases using homology searches and protein language models, with the most active one showing significant tumor reduction in mouse models.

Newly Sequenced Genomes Reveal Patterns of Gene Family Expansion in select Dragonflies (Odonata: Anisoptera)

This study identifies gene family expansions in two dragonfly families, linking them to ecological and life history traits, and finds Odonata has lower gene turnover than other insects.

Electrostatic encoding of genome organization principles within single native nucleosomes

This study shows that single nucleosomes encode A/B compartment information through biophysical properties, specifically condensability, which correlates with gene expression and is electrostatic in nature.

Tick extracellular vesicles alter keratinocyte function in the skin epidermis

This study shows that tick extracellular vesicles alter keratinocyte function in the epidermis by inhibiting proliferation and wound closure, linked to phosphoinositide 3-kinase, KGF-1, and TGF-β.

Proximity Labeling Expansion Microscopy (PL-ExM) resolves structure of the interactome

PL-ExM combines proximity labeling and expansion microscopy to visualize 3D interactome structures and assess PL technique performance.

Quantitative Three-dimensional Label-free Digital Holographic Imaging of Cardiomyocyte Size, Ploidy, and Cell Division

This study uses digital holographic imaging to show that mononucleated cardiomyocytes retain proliferative potential while binucleated cells have limited capacity to divide, with size thresholds affecting division ability.

Ultrahigh Resolution Lipid Mass Spectrometry Imaging of High-Grade Serous Ovarian Cancer Mouse Models

This study uses high-resolution MSI to analyze lipid changes in ovarian cancer mouse models, identifying biomarkers for diagnosis.

Co-transcriptional translation amplifies mRNA noise in Escherichia coli

This study shows co-transcriptional translation in E. coli increases mRNA noise by amplifying transcriptional variability and altering bursting kinetics.

Single-cell Transcriptional Analysis of the Cellular Immune Response in the Oral Mucosa of Mice

This study uses scRNA-seq to analyze immune cell changes in mouse oral mucosa across periodontal health, disease, and resolution conditions, identifying distinct macrophage subpopulations and markers associated with resolution.

Five amino acid mismatches in the zinc-finger domains of CELLULOSE SYNTHASE 5 and CELLULOSE SYNTHASE 6 modulate their incorporation into cellulose synthase complexes in Arabidopsis

The paper identifies five amino acid mismatches in CESA5 and CESA6 zinc-finger domains that affect their homodimerization and incorporation into cellulose synthase complexes in Arabidopsis.

The secreted midbody remnants, MBsomes, as a new class of mRNA nanocarrier applicable to diverse medical fields

The paper identifies MBsomes as mRNA nanocarriers capable of delivering genes and expresses EGFP when loaded with mRNA.

In Vivo Antiviral Efficacy of LCTG-002, a Pooled, Purified Human Milk Secretory IgA product, Against SARS-CoV-2 in a Murine Model of COVID-19

This study evaluates LCTG-002, a purified human milk sIgA product, showing it effectively reduces SARS-CoV-2 viral burden in mice.

Immunometabolic cues recompose and reprogram the microenvironment around biomaterials

The paper shows that immunometabolic cues around biomaterials influence immune cell trafficking and microenvironment composition, promoting a pro-regenerative state through metabolic reprogramming.

Plant-to-plant reactive oxygen signal transmission via a Cuscuta bridge

The paper shows that two plants connected by a Cuscuta bridge can exchange calcium, electric, and reactive oxygen species signals, suggesting potential benefits for plant communication.