Glycosaminoglycans are specific endosomal receptors for Yersinia pseudotuberculosis Cytotoxic Necrotizing Factor
G. Schmidt, S. Kowarschik, J. Schöllkopf, T. Mueller, S. Tian, J. Knerr, H. Bakker, S. Rein, M. Dong, S. Weber, R. Grosse
This paper identifies heparan sulfate proteoglycans as essential host factors for Yersinia pseudotuberculosis CNFY toxin intoxication, showing that conformational changes and heparanase activity are critical for toxin uptake and function.
bioRxiv · May 18, 2020 · PreprintPharmacology & Toxicology