R. Grosse

SUN2 mediates calcium-triggered nuclear actin polymerization to cluster active RNA polymerase II

The paper shows calcium triggers nuclear actin assembly via SUN2, which clusters RNA polymerase II.

Arp2/3 complex-dependent actin regulation protects the survival of tissue-resident mast cells

This study identifies the Arp2/3 complex as critical for maintaining mast cell survival and tissue residency through actin-dependent mechano-protection.

Replication fork plasticity upon replication stress requires rapid nuclear actin polymerization

This study shows that nuclear actin polymerization enables replication fork plasticity by facilitating fork slowing and reversal during replication stress.

Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation

The paper uses fluorescence microscopy to study protein clusters before condensation, finding dynamic clusters that are not freely diffusing and exist even in unstressed cells.

Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts

This study shows CAP2 regulates MRTF-A localization and SRF activity in MEFs, but not serum-induced changes.

Glycosaminoglycans are specific endosomal receptors for Yersinia pseudotuberculosis Cytotoxic Necrotizing Factor

This paper identifies heparan sulfate proteoglycans as essential host factors for Yersinia pseudotuberculosis CNFY toxin intoxication, showing that conformational changes and heparanase activity are critical for toxin uptake and function.

Post-mitotic expansion of cell nuclei requires ACTN4-mediated nuclear actin filament bundling

This study identifies ACTN4 as essential for postmitotic nuclear expansion by promoting actin filament bundling in the nucleus.

Actin chromobody imaging reveals sub-organellar actin dynamics

The paper develops a method to image sub-organellar actin dynamics using fluorescent actin nanobodies and finds ER-associated actin drives organelle fission.