G. Schmidt

Gain efficiency with streamlined and automated data processing: Examples from high-throughput monoclonal antibody production

The paper presents a modular data processing pipeline to streamline and automate data management in complex biological workflows, enhancing reproducibility and compliance with FAIR principles.

Sea squirt-inspired bio-derived tissue sealants

This paper develops bio-derived tissue sealants inspired by sea squirts, showing high adhesion performance and biocompatibility in rat skin incisions.

Genome wide CRISPR screen for Pasteurella multocida toxin (PMT) binding proteins reveals LDL Receptor Related Protein1 (LRP1) as crucial cellular receptor

The paper identifies LRP1 as a critical receptor for PMT toxin entry into cells using a CRISPR screen, showing its role in toxin binding and G protein activation.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

This study identifies TRIM67 as an oncogene in oligodendrogliomas that promotes cell motility, tumor growth, and membrane blebbing through Rho GTPase/ROCK signaling.

An inducible AraC that responds to blue light instead of arabinose

This paper introduces BLADE, a blue light-inducible AraC variant in E. coli that enables reversible control of gene expression and morphology, and uses it to study gene function and create bacteriographs.

Glycosaminoglycans are specific endosomal receptors for Yersinia pseudotuberculosis Cytotoxic Necrotizing Factor

This paper identifies heparan sulfate proteoglycans as essential host factors for Yersinia pseudotuberculosis CNFY toxin intoxication, showing that conformational changes and heparanase activity are critical for toxin uptake and function.

Identification of immunological features enables survival prediction of muscle-invasive bladder cancer patients using machine learning

This study uses machine learning to predict 5-year survival in muscle-invasive bladder cancer patients by analyzing immunological features from tissue images, outperforming the current TNM staging system.

Photorhabdus Luminescens Toxin complex (TCC) a recombinant injection nano-machine - delivery of recombinant Yersinia enterocolitica YopT

The paper describes engineering a toxin complex to deliver recombinant proteins into mammalian cells and demonstrates its efficiency for cargo delivery and quantification.