Author

J. Kosmatka

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Biophysics· 1

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Beck· 1 shared D. Toso· 1 shared E. Nogales· 1 shared M. Faini· 1 shared P. Sauer· 1 shared R. Aebersold· 1 shared S. Poepsel· 1 shared V. Kasinath· 1 shared

Activity by Year

2021-2021 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperBiophysics

C. Beck

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1 paper

Recent·Most cited

JARID2 and AEBP2 regulate PRC2 activity in the presence of H2A ubiquitination or other histone modifications

V. Kasinath, C. Beck, P. Sauer, S. Poepsel, J. Kosmatka, M. Faini, D. Toso, R. Aebersold, E. Nogales

This paper reports the cryo-EM structure of human PRC2 with cofactors JARID2 and AEBP2 bound to a nucleosome containing H2AK119ub1, revealing their roles in PRC2 activity regulation and histone modification crosstalk.

Science · Jan 22, 2021Peer-reviewedBiophysics