Author

V. Kasinath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 5 Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Assay:ChIP-seq· 1 Assay:metagenomics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

E. Nogales· 3 shared A. R. Gooding· 2 shared S. Poepsel· 2 shared T. R. Cech· 2 shared A. Lydecker· 1 shared C. Beck· 1 shared C. I. Sousa· 1 shared D. Toso· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiophysics

E. Nogales

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Author profile →

5 papers

Recent·Most cited

Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications

T. Cookis, A. Lydecker, P. V. Sauer, V. Kasinath, E. Nogales

The paper reveals how H3K4me3 and H3K36me3 inhibit PRC2 activity by blocking its interaction with chromatin and allosteric activators, using cryo-EM.

bioRxiv · Feb 9, 2024Biochemistry

Structural basis for inactivation of PRC2 by G-quadruplex RNA

J. Song, A. R. Gooding, W. O. Hemphill, V. Kasinath, T. R. Cech

The paper presents a cryo-EM structure of PRC2 bound to G-quadruplex RNA, revealing how RNA inhibits PRC2 by promoting dimerization and blocking DNA interaction.

bioRxiv · Feb 6, 2023Biochemistry

DNMT1 inhibition by pUG-fold quadruplex RNA

L. I. Jansson-Fritzberg, C. I. Sousa, M. J. Smallegan, J. J. Song, A. R. Gooding, V. Kasinath, J. L. Rinn, T. R. Cech

This study shows that DNMT1 interacts with pUG-fold RNA, which inhibits its activity by blocking DNA binding.

bioRxiv · Oct 14, 2022Biochemistry

JARID2 and AEBP2 regulate PRC2 activity in the presence of H2A ubiquitination or other histone modifications

V. Kasinath, C. Beck, P. Sauer, S. Poepsel, J. Kosmatka, M. Faini, D. Toso, R. Aebersold, E. Nogales

This paper reports the cryo-EM structure of human PRC2 with cofactors JARID2 and AEBP2 bound to a nucleosome containing H2AK119ub1, revealing their roles in PRC2 activity regulation and histone modification crosstalk.

Science · Jan 22, 2021Peer-reviewedBiophysics

Visualization of PRC2-Dinucleosome Interactions Leading to Epigenetic Repression

S. Poepsel, V. Kasinath, E. Nogales

The paper visualizes how PRC2 interacts with dinucleosomes to mediate epigenetic repression through cryo-EM structures.

bioRxiv · Jan 8, 2018Biophysics