Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
6 papers
Recent·Most cited
J. C. Brenner, L. C. Zirden, Y. Almeida-Hernandez…·D. Hellerschmied
This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.
P. V. Sauer, E. Pavlenko, T. Cookis…·S. Poepsel
The paper reveals a mechanism by which automethylated PRC2 dimerizes on chromatin to allosterically activate another PRC2 protomer for H3K27me3 methylation.
R. Winkler, A.-S. Mägdefrau, E.-M. Piskor…·C. Kosan
This study shows that inhibiting HDAC6 with Marbostat-100 reduces MYC levels and prevents lymphomagenesis in a mouse model of MYC-induced B-cell lymphoma.
V. Kasinath, C. Beck, P. Sauer…·E. Nogales
This paper reports the cryo-EM structure of human PRC2 with cofactors JARID2 and AEBP2 bound to a nucleosome containing H2AK119ub1, revealing their roles in PRC2 activity regulation and histone modification crosstalk.
K. Finogenova, J. Bonnet, S. Poepsel…·J. Müller
The paper determines how PRC2 is inhibited by H3K36 methylation through cryo-EM structures and shows that H3K36 mutations impair Polycomb repression.