Author

J. L. Fierst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Ecology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. M. Sutton· 2 shared L. T. Bubrig· 2 shared P. E. Adams· 2 shared A. Evans· 1 shared A. G. Anderson· 1 shared A. L. Crist· 1 shared C. Goltz· 1 shared E. Hagedorn· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersEvolutionary Biology

J. M. Sutton

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Author profile →

5 papers

Recent·Most cited

Genome size changes by duplication, insertion and divergence in Caenorhabditis worms

J. D. Milwood, J. M. Sutton, P. E. Adams, J. Pienaar, J. L. Fierst

This study investigates genome size variation in Caenorhabditis nematodes and finds that genome evolution occurs through small structural variants rather than deletions or transposable element dynamics.

bioRxiv · May 20, 2022 · PreprintEvolutionary Biology

Age-dependent impairment of disease tolerance is associated with a robust transcriptional response following RNA virus infection in Drosophila

L. Sheffield, N. Sciambra, A. Evans, E. Hagedorn, M. Delfeld, C. Goltz, J. L. Fierst, S. Chtarbanova

This study shows that aged Drosophila have impaired disease tolerance to RNA virus infection, marked by stronger transcriptional responses and altered gene regulation related to apoptosis and mitochondrial function.

bioRxiv · Sep 21, 2020Immunology

C. elegans dauer recovery varies with worm-bacteria interactions

L. T. Bubrig, J. M. Sutton, J. L. Fierst

The paper investigates C. elegans dauer recovery strategies in response to different bacteria, finding genotype-dependent recovery preferences that suggest a mix of discerning and undiscerning strategies.

bioRxiv · Apr 1, 2020Ecology

Slow recovery from inbreeding depression generated by the complex genetic architecture of segregating deleterious mutations

P. E. Adams, A. L. Crist, E. M. Young, J. H. Willis, P. C. Phillips, J. L. Fierst

This study investigates recovery from inbreeding depression in C. remanei, finding limited fitness recovery despite strong selection, due to the fixation of many segregating deleterious mutations.

bioRxiv · Dec 3, 2019Evolutionary Biology

Environmental stress maintains trioecy in nematode worms

A. G. Anderson, L. T. Bubrig, J. L. Fierst

The paper models the evolutionary dynamics of sex determination in Auanema freiburgensis, showing environmental stress maintains trioecy by stabilizing multiple reproductive systems.

bioRxiv · Dec 3, 2019Evolutionary Biology