Cell BiologybioRxivPreprint
Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal Protein
This study shows that loss of PGRN increases pan-cathepsin activity and reduces LAMP1 expression in MEFs, suggesting a role for PGRN in lysosomal function and inflammation.
DOI 10.1101/2023.07.15.549151