Author

J. L. Han

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Assay:electrophysiology· 2 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

E. Entcheva· 5 shared W. Liu· 3 shared C. J. Chua· 2 shared Y. Heinson· 2 shared G. Bub· 1 shared J. Tomek· 1 shared W. Li· 1 shared Y. W. Heinson· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 15 mutual co-author links

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5 shared papersBioengineering

E. Entcheva

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

OptoDyCE-plate as an affordable high throughput imager for all optical cardiac electrophysiology

Y. Heinson, J. L. Han, E. Entcheva

OptoDyCE-plate enables high-throughput optical cardiac electrophysiology in 96- and 384-well plates, showing drug response variability and pacing rate effects.

bioRxiv · Aug 29, 2023Bioengineering

CRISPRi Gene Modulation and All-Optical Electrophysiology in Post-Differentiated Human iPSC-Cardiomyocytes

J. L. Han, Y. W. Heinson, C. J. Chua, W. Liu, E. Entcheva

The paper uses CRISPRi and all-optical electrophysiology to study gene modulation effects in post-differentiated human iPSC-CMs, finding specific phenotype changes in cardiac ion channels.

bioRxiv · May 7, 2023Cell Biology

Simultaneous widefield voltage and interferometric dye-free optical mapping quantifies electromechanical waves in human iPSC-cardiomyocytes.

W. Liu, J. L. Han, J. Tomek, G. Bub, E. Entcheva

This study develops a method to simultaneously measure voltage and mechanical waves in human iPSC-CMs using dye-free optical imaging, revealing new insights into electromechanical coupling and its sensitivity to pharmacological agents.

bioRxiv · Oct 10, 2022Bioengineering

Portable low-cost macroscopic mapping system for all-optical cardiac electrophysiology

Y. Heinson, J. L. Han, E. Entcheva

The paper introduces a low-cost system for macroscopic all-optical cardiac electrophysiology in hiPSC-CMs, showing equivalency between electrical and optogenetic stimulation and demonstrating utility for studying cellular uncoupling agents.

bioRxiv · Apr 24, 2022Bioengineering

INTEGRATION OF ENGINEERED "SPARK-CELL" SPHEROIDS FOR OPTICAL PACING OF CARDIAC TISSUE

C. J. Chua, J. L. Han, W. Li, W. Liu, E. Entcheva

This study engineers 'spark-cell' spheroids to enable optical pacing of cardiac tissue, showing they can stimulate human stem-cell-derived cardiomyocytes faster than direct genetic modification.

bioRxiv · Jan 25, 2021Bioengineering