Author

J. Tomek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 2 Assay:imaging· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Assay:electrophysiology· 1

Frequent Co-Authors

B. Rodriguez· 2 shared E. Entcheva· 2 shared G. Bub· 2 shared A. Bueno-Orovio· 1 shared A. Klimas· 1 shared A. Kumar· 1 shared A. Quintanas· 1 shared A. R. Sharkey· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBioengineering

B. Rodriguez

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Author profile →

5 papers

Recent·Most cited

Simultaneous widefield voltage and interferometric dye-free optical mapping quantifies electromechanical waves in human iPSC-cardiomyocytes.

W. Liu, J. L. Han, J. Tomek, G. Bub, E. Entcheva

This study develops a method to simultaneously measure voltage and mechanical waves in human iPSC-CMs using dye-free optical imaging, revealing new insights into electromechanical coupling and its sensitivity to pharmacological agents.

bioRxiv · Oct 10, 2022Bioengineering

Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

X. Zhou, Z. J. Wang, J. Camps, J. Tomek, A. Santiago, A. Quintanas, M. Vazquez, M. Vaseghi, B. Rodriguez

This paper uses human ventricular electromechanical modelling to explain clinical phenotypes in acute and chronic myocardial infarction, showing that ionic remodelling impacts ECG changes and ejection fraction.

bioRxiv · Feb 15, 2022 · PreprintBioengineering

ToR-ORd-dynCl: an update of the ToR-ORd model of human ventricular cardiomyocyte with dynamic intracellular chloride

J. Tomek, A. Bueno-Orovio, B. Rodriguez

The paper updates the ToR-ORd model of human ventricular cardiomyocytes to include dynamic intracellular chloride, improving long-term simulation stability without significant complexity increase.

bioRxiv · Jun 1, 2020 · PreprintPhysiology

Optical interrogation of sympathetic neuronal effects on macroscopic cardiac monolayer dynamics

R. A. B. Burton, J. Tomek, C. M. Ambrosi, H. E. Larsen, A. R. Sharkey, R. A. Capel, S. Bilton, A. Klimas, G. Stephens, D. Li, G. Gallone, N. Herring, E. Mann, A. Kumar, H. Kramer, , G. Bub

This study uses optical methods to investigate how sympathetic neurons affect cardiac monolayer dynamics, focusing on neurotransmitter release, neuronal density effects, and optogenetics applications.

bioRxiv · Jul 30, 2019Biophysics

Widespread impact of DNA replication on mutational mechanisms in cancer

M. Tomkova, J. Tomek, S. Kriaucionis, B. Schuster-Boeckler

The paper quantifies how DNA replication timing and direction influence mutational signatures across 19 cancer types, finding that 22 out of 29 signatures are significantly affected.

bioRxiv · Aug 19, 2017Cancer Biology