Author

J. L. Nitiss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

K. C. Nitiss· 2 shared A. F. Bandak· 1 shared J. M. Berger· 1 shared J. Wereszczynski· 1 shared N. L. Kariyawasam· 1 shared S. Evoli· 1 shared T. R. Blower· 1 shared V. Shah· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

K. C. Nitiss

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Modeling Allosteric Mechanisms of Eukaryotic Type II Topoisomerases

S. Evoli, N. L. Kariyawasam, K. C. Nitiss, J. L. Nitiss, J. Wereszczynski

This study uses molecular dynamics simulations to investigate how nucleotide binding and hydrolysis regulate the allosteric mechanisms of yeast TopoII and how mutations affect these processes.

bioRxiv · Aug 2, 2023Biophysics

Using energy to go downhill - a genoprotective role for ATPase activity in DNA topoisomerase II

A. F. Bandak, T. R. Blower, K. c. Nitiss, V. Shah, J. L. Nitiss, J. M. Berger

This study shows that ATPase activity in type II topoisomerases prevents excessive DNA damage by regulating strand passage and cleavage.

bioRxiv · Jun 27, 2023Biochemistry