Author

T. R. Blower

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

D. M. Picton· 2 shared G. Mariano· 2 shared J. C. D. Hinton· 2 shared A. Beckett· 1 shared A. Bowers-Barnard· 1 shared A. F. Bandak· 1 shared B. M. Perez-Sepulveda· 1 shared C. V. Pulford· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersMicrobiology

D. M. Picton

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multi-conflict islands are a widespread trend within Serratia spp

T. Cummins, S. R. Garrett, T. R. Blower, G. Mariano

The paper identifies three defence islands in Serratia spp. with mixed cargo of anti-phage systems, virulence factors, and anti-bacterial modules, revealing a widespread trend of co-accumulation.

bioRxiv · Jan 28, 2024Microbiology

Using energy to go downhill - a genoprotective role for ATPase activity in DNA topoisomerase II

A. F. Bandak, T. R. Blower, K. c. Nitiss, V. Shah, J. L. Nitiss, J. M. Berger

This study shows that ATPase activity in type II topoisomerases prevents excessive DNA damage by regulating strand passage and cleavage.

bioRxiv · Jun 27, 2023Biochemistry

Shield co-opts an RmuC domain to mediate phage defence across Pseudomonas species.

E. Macdonald, H. Strahl, T. R. Blower, T. Palmer, G. Mariano

This paper identifies and characterizes a novel anti-phage system called Shield in Pseudomonas species, showing it can mediate bacterial immunity against phages through a membrane-bound protein with an RmuC domain.

PLOS Genetics · Jun 5, 2023Peer-reviewedMicrobiology

A widespread family of WYL-domain transcriptional regulators co-localises with diverse phage defence systems and islands

D. M. Picton, J. D. Harling-Lee, S. J. Duffner, S. C. Went, R. D. Morgan, J. C. D. Hinton, T. R. Blower

The paper identifies BrxR, a WYL-domain transcriptional regulator that represses phage defence systems and is widespread among bacteria, often co-localized with defence islands.

bioRxiv · Dec 19, 2021 · PreprintMicrobiology

Isolation and characterisation of bacteriophages with activity against invasive non-typhoidal Salmonella causing bloodstream infection in Malawi

E. V. Rodwell, N. Wenner, C. V. Pulford, Y. Cai, A. Bowers-Barnard, A. Beckett, J. Rigby, D. M. Picton, T. R. Blower, N. A. Feasey, J. C. D. Hinton, B. M. Perez-Sepulveda

This study isolates and characterizes bacteriophages active against invasive non-typhoidal Salmonella causing bloodstream infections in Malawi, identifying three phylogenetic clusters with varying host ranges.

bioRxiv · Feb 18, 2021Microbiology