Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis
C. D. Camell, A. Lee, P. Günther, E. L. Goldberg, O. Spadaro, Y.-H. Youm, A. Bartke, G. B. Hubbard, Y. Ikeno, N. H. Ruddle, J. L. Schultz, V. D. Dixit
This study shows aging increases adipose B cells and FALCs via Nlrp3 inflammasome, impairing metabolism, and B cell depletion improves metabolic function in aged mice.
bioRxiv · Apr 13, 2019Immunology