Author

V. D. Dixit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Research Focus:metabolism & bioenergetics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Y.-H. Youm· 3 shared A. Wang· 2 shared B. K. Hilliard· 2 shared C. D. Camell· 2 shared C. J. Booth· 2 shared E. L. Goldberg· 2 shared H. Qing· 2 shared I. Shchukina· 2 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersImmunology

Y.-H. Youm

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Adiponectin Preserves Metabolic Fitness During Aging

P. E. Scherer, N. Li, Z. Zhang, S. Zhao, Y. Zhu, C. M. Gliniak, L. Vishvanath, Y. A. An, M.-y. Wang, Y. Deng, Q. Zhu, T. Onodera, O. Oz, R. Gordillo, R. K. Gupta, , V. D. Dixit

This study shows that adiponectin improves healthspan and lifespan by enhancing insulin sensitivity and reducing age-related metabolic and inflammatory disorders in mice.

bioRxiv · Jan 14, 2021 · PreprintCell Biology

Type I Interferon Limits Viral Dissemination-Driven Clinical Heterogeneity in a Native Murine Betacoronavirus Model of COVID-19

H. Qing, L. Sharma, B. K. Hilliard, X. Peng, A. Swaminathan, J. Tian, K. Israni-Winger, C. Zhang, D. Leao, S. Ryu, V. Habet, L. Wang, X. Tian, S. Ishibe, L. H. Young, , A. Wang

This study establishes a murine model of COVID-19 using MHV-A59 and shows that type-I interferons limit viral dissemination, reducing lethality and recapitulating key clinical features.

bioRxiv · Sep 11, 2020 · PreprintImmunology

Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model

S. Ryu, I. Shchukina, Y.-H. Youm, H. Qing, B. K. Hilliard, T. Dlugos, X. Zhang, Y. Yasumoto, C. J. Booth, C. Fernandez-Hernando, Y. Suarez, K. M. Khanna, T. Horvath, M. O. Dietrich, M. Artyomov, , V. D. Dixit

This study shows that a ketogenic diet reduces inflammation and improves outcomes in aged mice infected with a coronavirus, suggesting potential therapeutic benefits for elderly COVID-19 patients.

bioRxiv · Sep 11, 2020 · PreprintImmunology

Dysregulation of adipose ILC2 underlies thermogenic failure in aging

E. L. Goldberg, I. Shchukina, Y.-H. Youm, C. D. Camell, T. Dlugos, M. Artyomov, V. D. Dixit

The paper identifies age-related changes in adipose tissue that reprogram ILC2, leading to impaired cold tolerance in aged mice.

bioRxiv · Sep 8, 2020 · PreprintImmunology

Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

C. D. Camell, A. Lee, P. Günther, E. L. Goldberg, O. Spadaro, Y.-H. Youm, A. Bartke, G. B. Hubbard, Y. Ikeno, N. H. Ruddle, J. L. Schultz, V. D. Dixit

This study shows aging increases adipose B cells and FALCs via Nlrp3 inflammasome, impairing metabolism, and B cell depletion improves metabolic function in aged mice.

bioRxiv · Apr 13, 2019Immunology