Author

J. Little

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:non-human primate· 1 Research Focus:phylogenetics / evolution· 1 Assay:protein sequence· 1

Frequent Co-Authors

A. Inoue· 1 shared A. R. B. Thomsen· 1 shared B. Plouffe· 1 shared C. Daly· 1 shared D. Juan· 1 shared D. M. Alba· 1 shared E. Cappellini· 1 shared E. Flores-Espinoza· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

A. Inoue

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Phylogenetic signal in primate tooth enamel proteins and its relevance for paleoproteomics

J. Krueger, R. Fong Zazueta, D. M. Alba, X. Aymerich, R. M. D. Beck, E. Cappellini, G. Carrillo Martin, O. Cirilli, N. Clark, O. E. Cornejo, K. Farh, L. Ferrandez-Peral, D. Juan, J. L. Kelley, L. F. K. Kuderna, , E. Lizano

The paper evaluates the reliability of phylogenetic inference using primate enamel proteins by simulating sequence fragmentation and comparing results to a reference species tree.

bioRxiv · Feb 28, 2024 · PreprintEvolutionary Biology

Evolutionary Rate Covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions

J. Little, M. Chikina, N. L. Clark

This study investigates whether evolutionary rate covariation (ERC) signals reflect physical interactions or other factors, finding weak evidence for physical coevolution and suggesting selective pressures may drive the signal.

bioRxiv · Oct 18, 2023Evolutionary Biology

Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration

H. Hahn, C. Daly, J. Little, N. A. Perry-Hauser, E. Flores-Espinoza, A. Inoue, B. Plouffe, A. R. B. Thomsen

This study shows endosomal chemokine receptor signaling, specifically through CCR7, enhances Rac1 activity and immune T cell chemotaxis by recruiting G protein and β-arrestin.

bioRxiv · Sep 27, 2022Cell Biology