Author

B. Plouffe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Inoue· 3 shared C. Daly· 3 shared A. R. B. Thomsen· 2 shared C. Le Gouill· 2 shared D. Veprintsev· 2 shared H. Hahn· 2 shared M. Bouvier· 2 shared A. A. Guseinov· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

A. Inoue

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multiple triggers converge to preferential effector coupling in the CB2R through a complex allosteric communication network

A. Morales-Pastor, T. Miljus, T. M. Stepniewski, V. Ledesma, F. Heydenreich, T. Flock, B. Plouffe, C. Le Gouill, J. Duchaine, W. Guba, A. Rufer, U. Grether, M. Bouvier, D. Veprintsev, J. Selent

The paper investigates how multiple triggers on an allosteric communication network influence preferential coupling of the CB2R to Gi2 over β-arrestin1, revealing insights into GPCR signaling mechanisms.

bioRxiv · Feb 27, 2024 · PreprintCell Biology

Structure of the human Duffy antigen receptor

S. Saha, B. Khanppnavar, J. Maharana, H. Kim, C. M. C. Carino, C. Daly, S. Houston, P. Kumari, P. N. Yadav, B. Plouffe, A. Inoue, K. Y. Chung, R. Banerjee, V. M. Korkhov, A. K. Shukla

This study determines the cryo-EM structure of the Duffy antigen receptor bound to CCL7, revealing structural features that explain its unique functional properties and lack of G protein coupling.

bioRxiv · Jul 9, 2023 · PreprintBiochemistry

β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

C. Daly, A. A. Guseinov, H. Hahn, A. Wright, I. Tikhonova, A. R. B. Thomsen, B. Plouffe

This study shows the vasopressin type 2 receptor can activate G proteins at endosomes both with and without beta-arrestin, challenging existing models of GPCR signaling.

bioRxiv · Apr 1, 2023Cell Biology

Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration

H. Hahn, C. Daly, J. Little, N. A. Perry-Hauser, E. Flores-Espinoza, A. Inoue, B. Plouffe, A. R. B. Thomsen

This study shows endosomal chemokine receptor signaling, specifically through CCR7, enhances Rac1 activity and immune T cell chemotaxis by recruiting G protein and β-arrestin.

bioRxiv · Sep 27, 2022Cell Biology

Vasopressin V2 is a promiscuous G protein-coupled receptor that is biased by its peptide ligands

F. M. Heydenreich, B. Plouffe, A. Rizk, D. Milic, J. Zhou, B. Breton, C. Le Gouill, A. Inoue, M. Bouvier, D. Veprintsev

The paper shows that the vasopressin V2 receptor activates multiple G proteins and that its signaling can be biased by ligand structure.

bioRxiv · Jan 28, 2021 · PreprintPharmacology & Toxicology