Deubiquitinase UCHL1 Maintains Protein Homeostasis through PSMA7-APEH-Proteasome Axis in High-Grade Serous Ovarian Carcinoma
A. Tangri, K. Lighty, J. Loganathan, F. Mesmar, R. Podicheti, C. Zhang, M. Iwanicki, H. Nakshatri, S. Mitra
This study identifies UCHL1's role in maintaining protein homeostasis in HGSOC via the PSMA7-APEH-proteasome axis, showing its importance for tumor growth and suggesting therapeutic targeting.
bioRxiv · Sep 28, 2020Cancer Biology