S. Mitra

An epigenetically distinct HSC subset supports thymic reconstitution

This study identifies an epigenetically distinct HSC subset, Kitlo, that supports better thymic and T-cell reconstitution in mice and humans.

Co-existence of plasmid-mediated blaNDM-1 and blaNDM-5 in Escherichia coli sequence type 167 and ST101 and their discrimination through restriction digestion

This study identifies and characterizes co-existing blaNDM-1 and blaNDM-5 variants in E. coli isolates using Sanger sequencing and hybrid assembly, and develops a restriction digestion method to distinguish them.

Sex-specific fear acquisition following early life stress is linked to amygdala glutamate metabolism

This study examines sex-specific effects of early life stress on fear memory and amygdala metabolism, revealing sex-dependent changes in glutamate and metabolic pathways.

ABI3 regulates ABI1 function to control cell length in primary root elongation zone

This study shows ABI3 regulates JAZ1 and ABI1 to control cell length in primary root elongation by modulating protonation of the apoplast.

Fusobacterium nucleatum present in the saliva of oral cancer subjects can activate niche defense of oral squamous cell carcinoma

The paper investigates how Fusobacterium nucleatum in saliva activates a tumor stemness defense phenotype in oral cancer stem cells, contributing to cancer progression and relapse.

Gestures Of Hunger: Uncovering Intentional Gestural Communication In Free-Ranging Hanuman Langurs

This study identifies intentional gestural communication in Hanuman langurs, showing they use learned gestures to request food from humans and adapt this behavior as a foraging strategy.

Hsp70/Hsp90 organizing protein (HOP) maintains CRAF kinase activity and regulates MAPK signaling by enhancing Hsp90-CRAF association

Role of maternal, fetal and placental histopathology factors in the pathogenesis of retinopathy of prematurity.

The paper investigates maternal, fetal, and placental factors predicting retinopathy of prematurity risk in preterm infants using histopathology and molecular analysis.

Hypothalamic Protein Profiling from Mice Subjected to Social Defeat Stress

This study identifies stress-induced protein changes in the hypothalamus of mice subjected to social defeat stress using iTRAQ proteomics, highlighting potential biomarkers for depression.

Spatial transcriptomic analysis of childhood ependymoma implicates unresolved wound healing as a driver of tumor progression

This study uses spatial transcriptomics to analyze childhood ependymoma, revealing unresolved wound healing as a driver of tumor progression through distinct cellular interactions and states.

Targeting tumor stemness switch phenotype by activating pathogen induced stem cell niche defense

The paper shows that tumor stemness switch phenotype CSCs undergo bystander apoptosis when infected with BCG or Mtb, activating a niche defense mechanism with anti-tumor and anti-microbial effects.

Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular program

This study identifies a TRP120 SLiM ligand mimetic from Ehrlichia chaffeensis that activates Hedgehog signaling to induce BCL-2 expression and inhibit apoptosis, facilitating bacterial infection.

The Transcription Factor Xrp1 is Required for PERK-Mediated Antioxidant Gene Induction in Drosophila

The paper shows that Xrp1, not ATF4, mediates PERK-induced antioxidant gene expression in Drosophila through a conserved uORF mechanism.

Spatially Patterned Bi-electrode Epiretinal Stimulation for Axon Avoidance at Cellular Resolution

This paper tests bi-electrode stimulation to reduce axon activation in retinal ganglion cells, improving selectivity at single-cell resolution.

Pilot study: Trehalose-induced remodelling of the human microbiota affects Clostridioides difficile infection outcome in an in vitro colonic model

This study shows that trehalose supplementation remodels the human gut microbiota, preventing simulated Clostridioides difficile infection in an in vitro model.

Automatic Identification and Avoidance of Axon Bundle Activation for Epiretinal Prosthesis

The paper develops an algorithm to detect axon bundle activation thresholds in retinal prostheses using electrical recordings, validated in macaque retina experiments.

Role of extracellular mycobacteria in blood-retinal barrier invasion in a zebrafish model of ocular TB

This study examines how extracellular and intracellular mycobacteria invade the blood-retinal barrier in a zebrafish model of ocular TB, showing different disease progression outcomes based on invasion mode.

Altered food habits? Understanding the feeding preference of free-ranging Grey langur (Semnopithecus entellus) within an urban settlement.

This study examines the feeding preferences of free-ranging grey langurs in an urban setting, finding they prefer urban food items over natural ones due to resource scarcity and human interaction.

Deubiquitinase UCHL1 Maintains Protein Homeostasis through PSMA7-APEH-Proteasome Axis in High-Grade Serous Ovarian Carcinoma

This study identifies UCHL1's role in maintaining protein homeostasis in HGSOC via the PSMA7-APEH-proteasome axis, showing its importance for tumor growth and suggesting therapeutic targeting.

Neoplastic and Immune single cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.

The paper uses single-cell transcriptomics to identify subgroup-specific neoplastic and immune cell heterogeneity in childhood medulloblastoma.

Comprehensive analysis of genomic diversity of SARS-CoV-2 in different geographic regions of India: An endeavour to classify Indian SARS-CoV-2 strains on the basis of co-existing mutations

This study analyzes SARS-CoV-2 genomic diversity in India, identifying 33 mutations and classifying strains into 22 groups based on co-existing mutations.

5' UTR recruitment of eIF4GI or DAP5 drives cap-independent translation for a subset of human mRNAs

The paper identifies that eIF4GI and DAP5 bind to 5' UTRs of specific mRNAs, enabling cap-independent translation under stress conditions.

CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci

The paper identifies CDK8 as a negative regulator of STAT3 transcriptional activity in Th-1 cells, showing it limits STAT3's resident time at gene loci, thereby modulating IL-6 responses.

Engineered IL-10 variants elicit potent immuno-modulatory activities at therapeutic low ligand doses

This study engineered IL-10 variants with enhanced receptor affinity, showing improved bioactivity and gene expression at lower doses in human monocytes and CD8 T cells.

Profiling the effects of rifaximin on the healthy human colonic microbiota using a chemostat model

This study evaluates three rifaximin formulations on the human colonic microbiota using chemostat models, finding that formulation {kappa} caused the least disruption.

Microbiota supplementation with Bifidobacterium and Lactobacillus modifies the preterm infant gut microbiota and metabolome

This study shows that supplementing preterm infants with Bifidobacterium and Lactobacillus changes their gut microbiota and increases fecal acetate and lactate levels, resembling a full-term infant's gut environment.

RNF144A shapes the hierarchy of cytokine signaling to provide protective immunity against influenza

RNF144A regulates cytokine signaling hierarchy in T cells to enhance anti-influenza immunity by promoting STAT5 activation and limiting MAPK signaling.

Molecular profiling of driver events and tumor-infiltrating lymphocytes in metastatic uveal melanoma

This study profiles genomic and transcriptomic features of metastatic uveal melanoma, identifying BAP1 inactivation and immune checkpoint receptor expression in tumor-infiltrating lymphocytes.

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

The paper investigates how cytokine receptor binding kinetics affect signaling outcomes by engineering IL-6 variants with different affinities to gp130.

Genetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin and the associated centromere complex

The paper identifies SENP6 as a SUMO protease critical for maintaining centromeric chromatin and the centromere complex through dynamic SUMO regulation.