R. Podicheti

Quorum Sensing Regulates Virulence Factors in the Coral Pathogen Vibrio coralliilyticus

This study identifies an active quorum sensing pathway in Vibrio coralliilyticus that regulates virulence factors like proteases, biofilms, and type VI secretion systems.

Bacterium secretes chemical inhibitor that sensitizes competitor to bacteriophage infection

The paper identifies a bacterial secondary metabolite that sensitizes competitors to phage infection, providing a fitness advantage to the producer.

A novel ALDH1A1 inhibitor blocks platinum-induced senescence and stemness in ovarian cancer

This study identifies a novel ALDH1A1 inhibitor that suppresses chemotherapy-induced senescence and stemness in ovarian cancer stem cells, suggesting its potential for clinical use.

Reciprocal interactions between the gut microbiome and mammary tissue mast cells promote metastatic dissemination of HR+ breast tumors

This study shows that an inflammatory gut microbiome promotes early metastasis of HR+ breast tumors by increasing mast cell activity in mammary tissue.

Aberrant epigenetic and transcriptional events associated with breast cancer risk

This study identifies molecular aberrations in normal breast tissue from high-risk women, linking epigenetic and transcriptional changes to breast cancer susceptibility.

The polar flagellar transcriptional regulatory network in Vibrio campbellii deviates from canonical Vibrio species

This study identifies differences in the flagellar regulatory network of Vibrio campbellii compared to other Vibrio species using genetic and transcriptomic analyses.

The ChiS-family DNA-binding domain contains a cryptic helix-turn-helix variant

The paper determines the crystal structure of the ChiS DNA-binding domain in Vibrio cholerae, revealing a novel helix-sheet-helix variant of the HTH domain and its role in DNA binding.

Deubiquitinase UCHL1 Maintains Protein Homeostasis through PSMA7-APEH-Proteasome Axis in High-Grade Serous Ovarian Carcinoma

This study identifies UCHL1's role in maintaining protein homeostasis in HGSOC via the PSMA7-APEH-proteasome axis, showing its importance for tumor growth and suggesting therapeutic targeting.

The quorum-sensing systems of Vibrio campbellii DS40M4 and BB120 are genetically and functionally distinct

This paper compares the quorum-sensing systems of Vibrio campbellii DS40M4 and BB120, finding genetic and functional differences in autoinducer production, regulatory mechanisms, and regulon size.

Diversity in natural transformation frequencies and regulation across Vibrio species

The paper shows that Vibrio species exhibit diverse natural transformation capabilities, with TfoX and QstR expression enabling high transformation rates in some strains but not others.

Plant Extracellular Vesicles Contain Diverse Small RNA Species and Are Enriched in 10 to 17 Nucleotide \"Tiny\" RNAs

The paper identifies diverse small RNA species in plant extracellular vesicles, including a novel class of 10-17 nt 'tiny' RNAs enriched in EVs.

RNA polymerases IV and V influence the 3’ boundaries of Polymerase II transcription units in Arabidopsis

The paper shows that RNA polymerases IV and V influence the 3’ boundaries of Pol II transcription units in Arabidopsis by affecting Pol II occupancy downstream of poly A sites.