Adoptive Transfer of CD49a+ Tissue Resident memory cells reverses pulmonary fibrosis in mice.
S. L. Collins, Y. Chan-Li, K. Shenderov, A. M. Nelson, J. M. Loube, W. A. Mitzner, J. D. Powell, M. R. Horton, A. Gillich
This paper demonstrates that adoptive transfer of CD49a+ CD4+ tissue resident memory T cells reverses established pulmonary fibrosis in mice by reducing collagen and improving lung function.
bioRxiv · Mar 13, 2024 · PreprintImmunology