Structural and biophysical characterisation of ubiquitin variants that specifically inhibit the ubiquitin conjugating enzyme Ube2d2
J. M. McAlpine, J. Zhu, N. Pudjihartono, J. Teyra, M. J. Currie, R. C. Dobson, S. S. Sidhu, C. L. Day, A. J. Middleton
The paper identifies ubiquitin variants that inhibit Ube2d2, showing structural and biophysical properties that suggest potential for developing selective E2 enzyme inhibitors.
bioRxiv · Mar 10, 2024Biochemistry