Type III interferons induce pyroptosis in gut epithelial cells and delay tissue restitution upon acute intestinal injury.
B. Sposito, J. Mambu, K. Bugda Gwilt, L. Spinelli, N. Andreeva, F. Galland, P. Naquet, V. Mitsialis, J. R. Thiagarajah, S. Snapper, A. Broggi, I. Zanoni
This study shows type III interferons delay intestinal tissue repair by inducing pyroptosis in epithelial cells after injury.
bioRxiv · Mar 4, 2022 · PreprintImmunology