S. Snapper

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.

This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.

IL-10 inhibits STAT1-dependent macrophage accumulation during microbiota-induced colitis

The paper shows IL-10R inhibits STAT1-dependent macrophage accumulation in colitis by preventing a cell-extrinsic signal, not directly affecting STAT1 function.

Group 3 Innate Lymphoid Cells are regulated by WASP in a microbiota-dependent manner

This study shows that WASP is essential for ILC3 development and function in the presence of commensal bacteria, with reduced ILC3s and increased susceptibility to infection in WASP-deficient mice.

Type III interferons induce pyroptosis in gut epithelial cells and delay tissue restitution upon acute intestinal injury.

This study shows type III interferons delay intestinal tissue repair by inducing pyroptosis in epithelial cells after injury.

Treatment-Specific Composition of Gut Microbiota Is Associated with Disease Remission in a Pediatric Crohn’s Disease Cohort

This study examines how gut microbiota changes with metronidazole and metronidazole plus azithromycin treatments in pediatric Crohn’s disease and finds that microbiota profiles can predict disease remission.

Aerodigestive sampling reveals altered microbial exchange between lung, oropharyngeal, and gastric microbiomes in children with impaired swallow function

This study examines microbial exchange between lung, oropharyngeal, and gastric microbiomes in children with impaired swallow function, finding increased similarity between lung and oropharyngeal microbiomes in those with aspiration.