Author

B. Sposito

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Broggi· 3 shared I. Zanoni· 3 shared N. Clementi· 2 shared N. Mancini· 2 shared A. Ambrosi· 1 shared A. Bottazzi· 1 shared A. Lo Cascio· 1 shared A. Pontiroli· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersImmunology

A. Broggi

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3 papers

Recent·Most cited

Type III interferons induce pyroptosis in gut epithelial cells and delay tissue restitution upon acute intestinal injury.

B. Sposito, J. Mambu, K. Bugda Gwilt, L. Spinelli, N. Andreeva, F. Galland, P. Naquet, V. Mitsialis, J. R. Thiagarajah, S. Snapper, A. Broggi, I. Zanoni

This study shows type III interferons delay intestinal tissue repair by inducing pyroptosis in epithelial cells after injury.

bioRxiv · Mar 4, 2022 · PreprintImmunology

Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients.

B. Sposito, A. Broggi, L. Pandolfi, S. Crotta, R. Ferrarese, S. Sisti, N. Clementi, A. Ambrosi, E. Liu, V. Frangipane, L. Saracino, L. Marongiu, F. Facchini, A. Bottazzi, T. Fossali, , I. Zanoni

This study examines IFN-I and IFN-III expression patterns in the respiratory tract of COVID-19 patients, finding higher IFN-III levels in severe cases and varying roles across anatomical sites.

bioRxiv · Mar 30, 2021 · PreprintImmunology

Type III interferons disrupt the lung epithelial barrier upon viral recognition.

A. Broggi, S. Ghosh, B. Sposito, R. Spreafico, F. Balzarini, A. Lo Cascio, N. Clementi, M. De Santis, N. Mancini, F. Granucci, I. Zanoni

This study shows that type III interferons from lung dendritic cells damage the epithelial barrier and increase susceptibility to bacterial infections during viral recognition.

bioRxiv · May 5, 2020Immunology