I. Zanoni

Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.

The paper shows host-derived oxidized phospholipids initiate effector-triggered immunity, leading to lethality upon microbial encounter, and demonstrates that blocking oxPLs reduces inflammation and host death.

Correction of age-associated defects in dendritic cell functions enables CD4+ T cells to eradicate tumors in the elderly

This study shows that CD4+ T cells, supported by hyperactivator-stimulated dendritic cells, can eliminate tumors in elderly mice, suggesting a strategy to correct age-related immune defects.

Prioritized single-cell proteomics reveals molecular and functional polarization across primary macrophages

The paper introduces pSCoPE, a single-cell proteomics method that improves sensitivity, completeness, and depth, enabling analysis of protein variation in macrophages.

Type III interferons induce pyroptosis in gut epithelial cells and delay tissue restitution upon acute intestinal injury.

This study shows type III interferons delay intestinal tissue repair by inducing pyroptosis in epithelial cells after injury.

An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice

This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.

An integrated pipeline and multi-model graphical user interface for accurate nano-dosimetry

The paper introduces a pipeline and software tool for accurate nano-dosimetry, showing that effective dose estimation requires rigorous characterization of nanoparticle-cell stickiness.

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients.

This study examines IFN-I and IFN-III expression patterns in the respiratory tract of COVID-19 patients, finding higher IFN-III levels in severe cases and varying roles across anatomical sites.

Type III interferons disrupt the lung epithelial barrier upon viral recognition.

This study shows that type III interferons from lung dendritic cells damage the epithelial barrier and increase susceptibility to bacterial infections during viral recognition.

The physical form of microbial ligands bypasses the need for dendritic cell migration to stimulate adaptive immunity

This study shows that soluble fungal polysaccharides are immunosilent in peripheral tissues but become potent immunogens in draining lymph nodes without requiring dendritic cell migration.

Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence

This study shows that Pho84 in Candida albicans affects virulence by modulating oxidative stress through Sod3 and TORC1 pathways.