Author

J. Mieczkowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

B. Kaminska· 4 shared B. Gielniewski· 2 shared K. B. Leszczynska· 2 shared K. Wojnicki· 2 shared M. Dzwigonska· 2 shared W. Grajkowska· 2 shared A. Dziedzic· 1 shared A. J. Giaccia· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersCancer Biology

B. Kaminska

Mutual co-authors in cluster

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4 papers

Recent·Most cited

H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in paediatric high-grade glioma cells

K. B. Leszczynska, A. Pereira de Freitas, C. Jayaprakash, M. Dzwigonska, K. Wojnicki, B. Gielniewski, P. Szadkowska, B. Kaza, M. K. Ciolkowski, J. Trubicka, W. Grajkowska, B. Kaminska, J. Mieczkowski

This study shows HDAC inhibitors reduce H3.3K27M protein levels in glioma cells, with H2A.Z facilitating this effect, suggesting a potential therapeutic strategy for DIPG.

bioRxiv · May 15, 2023Cancer Biology

Hypoxia-mediated regulation of DDX5 through decreased chromatin accessibility and post-translational targeting restricts R-loop accumulation

K. B. Leszczynska, M. Dzwigonska, H. Estephan, J. Moehlenbrink, E. Bowler, A. J. Giaccia, J. Mieczkowski, B. Kaminska, E. M. Hammond

The paper shows hypoxia reduces DDX5 expression by decreasing chromatin accessibility and post-translational targeting, which limits R-loop accumulation in cancer cells.

bioRxiv · Apr 30, 2022Cancer Biology

Single-cell RNA sequencing reveals functional heterogeneity and sex differences of glioma-associated brain macrophages

N. Ochocka, P. Segit, K. A. Walentynowicz, K. Wojnicki, S. Cyranowski, J. Swatler, J. Mieczkowski, B. Kaminska

This study uses scRNA-seq to identify functional heterogeneity and sex differences in myeloid cells in gliomas.

bioRxiv · May 20, 2020 · PreprintCancer Biology

Mapping chromatin accessibility and active regulatory elements reveals new pathological mechanisms in human gliomas

K. Stepniak, M. A. Machnicka, J. Mieczkowski, A. Macioszek, B. Wojtas, B. Gielniewski, S. K. Krol, R. Guzik, M. J. Dabrowski, M. Draminski, M. Jardanowska, I. Grabowicz, A. Dziedzic, H. Kranas, K. Sienkiewicz, , B. Wilczynski

The paper maps chromatin accessibility and regulatory elements in human gliomas to identify new epigenetic mechanisms driving cancer progression.

bioRxiv · Mar 20, 2020Cancer Biology