Cancer BiologybioRxivPreprint
CKS1-dependent proteostatic regulation has dual roles combating acute myeloid leukemia whilst protecting normal hematopoiesis
W. Grey, A. Rio-Machin, P. Casado-Izquierdo…·D. Bonnet
This study identifies CKS1-dependent proteostasis as a dual target for combating AML while protecting normal hematopoiesis through inhibition of SCFSKP2-CKS1.
DOI 10.1101/2020.12.27.423419