Disclosing the actual efficiency of G-quadruplex DNA-disrupting small molecules
J. Mitteaux, P. Lejault, M. Pirrotta, F. Wojciechowski, A. Joubert, N. Desbois, C. P. Gros, R. H. E. Hudson, J.-B. Boule, A. Granzhan, D. Monchaud
The paper develops an in vitro assay to identify G4-disrupting molecules and characterizes a prototype small molecule that destabilizes G4-DNA.
bioRxiv · Nov 16, 2020Biophysics