Author

D. Monchaud

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Mitteaux· 2 shared M. Pirrotta· 2 shared P. Lejault· 2 shared A. Cammas· 1 shared A. Granzhan· 1 shared A. Joubert· 1 shared A. Pipier· 1 shared B. Datta· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

J. Mitteaux

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

G-quadruplex formation in long non-coding RNAs dysregulated in colorectal cancer

S. Sharma, C. Shukla, J. Mitteaux, A. Pipier, M. Pirrotta, M.-J. Penouilh, D. Monchaud, B. Datta

This study investigates G-quadruplex (G4) formation in three lncRNAs dysregulated in colorectal cancer and shows their stable G4 structures using in silico and in vitro methods.

bioRxiv · Jul 4, 2024 · PreprintBiochemistry

RNA G-quadruplex dynamic steers the crosstalk between protein synthesis and energy metabolism

L. Dumas, S. Shin, Q. Rigaud, M. Cargnello, B. Hernandez-Suarez, P. Herviou, N. Saint-Laurent, M. Leduc, M. Le Gall, D. Monchaud, E. Dassi, A. Cammas, S. Millevoi

The paper shows RNA G-quadruplexes regulate mitochondrial function by modulating cytoplasmic mRNA translation of nuclear-encoded mitochondrial proteins, impacting energy metabolism and cancer cell proliferation.

bioRxiv · Jan 29, 2024 · PreprintCancer Biology

Biomimetic, smart and multivalent ligands for G-quadruplex isolation and bioorthogonal imaging

F. Rota Sperti, T. Charbonnier, P. Lejault, J. Zell, C. Bernhard, I. E. Valverde, D. Monchaud

This paper introduces biomimetic, multivalent ligands (TASQs) for isolating and imaging G-quadruplexes in human cells using affinity capture and biotin/avidin pretargeted imaging.

bioRxiv · Dec 18, 2020Biophysics

Disclosing the actual efficiency of G-quadruplex DNA-disrupting small molecules

J. Mitteaux, P. Lejault, M. Pirrotta, F. Wojciechowski, A. Joubert, N. Desbois, C. P. Gros, R. H. E. Hudson, J.-B. Boule, A. Granzhan, D. Monchaud

The paper develops an in vitro assay to identify G4-disrupting molecules and characterizes a prototype small molecule that destabilizes G4-DNA.

bioRxiv · Nov 16, 2020Biophysics

Insights into G-Quadruplex-Hemin Dynamics Using Atomistic Simulations: Implications for Reactivity and Folding

P. Stadlbauer, B. Islam, M. Otyepka, J. Chen, D. Monchaud, J. Zhou, J.-L. Mergny, J. Sponer

This study uses atomistic simulations to investigate G4-hemin interactions, revealing dynamic binding mechanisms and suggesting hemin's role in G4 folding.

bioRxiv · Nov 9, 2020Biophysics