Activation of the Aryl Hydrocarbon Receptor in Endothelial Cells Impairs Ischemic Angiogenesis in Chronic Kidney Disease
V. Palzkill, J. Tan, Q. Yang, J. Morcos, O. Laitano, T. E. Ryan
This study shows that deleting the AHR in endothelial cells improves ischemic angiogenesis in male CKD mice but not females, revealing sex-dependent differences in AHR activation and angiogenic signaling.
bioRxiv · Jul 24, 2023 · PreprintPhysiology