J. Tan

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

The paper characterizes human antibodies against PfRH5, identifies key features of potent inhibitors, and demonstrates their prophylactic potential against malaria.

High fat low carbohydrate diet is linked to protection against CNS autoimmunity

This study links a high fat low carbohydrate diet to protection against CNS autoimmunity by showing reduced neuroinflammation and immunometabolic changes in a mouse model.

Two mechanisms of photoenergy regulation revealed by kinetic behaviors of chlorophyll fluorescence during light adaptation

The paper identifies two mechanisms of photoenergy regulation in PSII using chlorophyll fluorescence kinetics: one involving PsbS-mediated NPQ and another involving zeaxanthin and lutein disrupting energy transfer to P680.

Mitochondrial DNA is a sensitive surrogate and oxidative stress target in oral cancer cells

This study develops a method to quantify mtDNA damage, repair, and copy number changes in oral cancer cells under oxidative stress and finds differential responses compared to normal cells.

Structural basis of the bacterial flagellar motor rotational switching

This study presents cryo-EM structures of the bacterial flagellar motor C ring in two rotational states, revealing the structural basis of directional switching.

A 6-minute Limb Function Assessment for Therapeutic Testing in Experimental Peripheral Artery Disease Models

This paper develops a 6-minute limb function test for preclinical hindlimb ischemia models to assess muscular performance and hemodynamics, showing it detects therapeutic differences better than traditional measures.

Nanoparticles alter the nature and strength of intraploidy and interploidy interactions in plants

This study investigates how copper oxide nanoparticles affect intraploidy and interploidy interactions in polyploid and diploid Fragaria plants, revealing ploidy-specific changes in competition and facilitation.

Gut microbes of the cecum versus the colon drive more severe lethality and multi-organ damage

This study compares the severity of sepsis caused by intestinal perforations in the cecum versus colon, finding that cecum perforations lead to more severe outcomes due to higher bacterial burden and pathogenic microbial abundance.

Thyroid Hormone Suppresses Medulloblastoma Progression Through Promoting Terminal Differentiation of Tumor Cells

This study shows thyroid hormone promotes differentiation of medulloblastoma cells, reducing tumor growth by reversing EZH2-mediated repression of NeuroD1.

Functional characterization of CCHamides and deorphanization of their receptors in the yellow fever mosquito, Aedes aegypti

This paper characterizes CCHamides and their receptors in Aedes aegypti, showing their expression patterns and functional role in feeding behavior.

Self-inspired learning to denoise for live-cell super-resolution microscopy

This paper introduces SN2N, a self-supervised denoising method for live-cell super-resolution microscopy that achieves competitive performance without requiring large clean datasets.

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Mouse Model

This paper develops a biologically inspired microbead platform for inducing chronic ocular hypertension in mice, leading to retinal ganglion cell loss and visual pathway impairment.

Targeting transcription factors through an IMiD independent zinc finger domain

This study identifies a new IMiD-independent drug targeting SALL4's ZFC4 domain, leading to significant tumor growth inhibition in vivo.

Oblique Line Scan Illumination Enables Expansive, Accurate and Sensitive Single Protein Measurements in Solution and in Living Cells

This paper introduces Oblique Line Scan (OLS) illumination to enhance single-molecule tracking in living cells and solution, enabling high-throughput and sensitive protein dynamics measurements.

Assessing Immune Factors in Maternal Milk and Paired Infant Plasma Antibody Binding to Human Rhinoviruses

The paper identifies maternal milk and infant plasma antibody binding to human rhinovirus epitopes using high-density peptide arrays, revealing isotype-specific and virus-specific binding patterns.

Breastfeeding enhances intestinal gluconeogenesis in infants

This study reanalyzes microarray data to show breastfeeding enhances intestinal gluconeogenesis in infants, similar to observations in other mammals.

Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

The paper identifies potent neutralizing antibodies against the malaria antigen RH5 from natural infection, showing they target similar epitopes as vaccine-induced antibodies.

A unique human cord blood CD8+CD45RA+CD27+CD161+ T cell subset identified by flow cytometric data analysis using Seurat

Activation of the Aryl Hydrocarbon Receptor in Endothelial Cells Impairs Ischemic Angiogenesis in Chronic Kidney Disease

This study shows that deleting the AHR in endothelial cells improves ischemic angiogenesis in male CKD mice but not females, revealing sex-dependent differences in AHR activation and angiogenic signaling.

Chronic activation of the aryl hydrocarbon receptor in muscle exacerbates ischemic pathology in chronic kidney disease

This study shows chronic AHR activation in muscle worsens ischemic damage in CKD and PAD by impairing muscle function and mitochondrial health.

Plasma cells are formed in waning germinal centers via an affinity-independent process

The paper tracks Ighg2A10 cells in germinal centers using single-cell RNA-seq and finds that plasma cells form in waning GCs through an affinity-independent process.

Environments and host genetics influence the geographic distribution of plant microbiome structure

The paper investigates how environmental factors and host genetics shape the geographic distribution of duckweed microbiomes, finding temperature, sodium concentration, and host genetic variation significantly influence bacterial richness and community composition.

Trophic interactions in microbiomes influence plant host population size and ecosystem function

This study examines how predation and parasitism within microbiomes affect plant population size and ecosystem function using duckweed.

Label-free and high-throughput removal of residual undifferentiated cells from iPSC-derived spinal-cord progenitor cells

This study removes residual undifferentiated iPSCs from spinal-cord progenitor cells using size-based microfluidic separation, reducing OCT4-positive cells without affecting viability.

Enhancing detectable fluorescence fluctuation for high-throughput and four-dimensional live-cell super-resolution imaging

This paper introduces SACD, a super-resolution imaging method that reduces acquisition time and improves resolution, enabling high-throughput and 4D live-cell imaging.

Quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation

This paper introduces a method to quantitatively map the local quality of super-resolution microscopy images, enabling better integration of reconstructions and detection of uncertainties.

Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells

This study shows that increasing oxygen levels in cell culture improves metabolic function and responsiveness in terminally differentiated cells like adipocytes and hepatocytes.

QCR7 affects the virulence of Candida albicans and the uptake of multiple carbon sources present in different host niches

Immunity induced by vaccination with recombinant influenza B virus neuraminidase protein breaks viral transmission chains in guinea pigs in an exposure intensity-dependent manner

This study shows that an intranasal recombinant influenza B virus neuraminidase vaccine can block viral transmission in guinea pigs depending on exposure intensity.

Emerging Evidence for Poxvirus-Mediated Unfolded Protein Response: Lumpy Skin Disease Virus Maintains Self-replication by Activating PERK and IRE1

This study shows that lumpy skin disease virus activates PERK and IRE1 pathways to support its replication, suggesting potential therapeutic targets for poxvirus infections.