Influenza infected macrophages release viral ribonucleoproteins that shape the local host response
S. Fritzlar, S. Lakdawala, J. A. Roberts, L. J. M. Coin, Y.-M. Deng, J. Moselen, V. Le Sage, J. Mackenzie, L. Labzin, A. G. Brooks, P. Reading, S. Londrigan
This study shows that influenza-infected macrophages release viral ribonucleoproteins (vRNPs) that trigger inflammatory responses in uninfected cells through the RIG-I/MDA5 pathway.
bioRxiv · Dec 4, 2023 · PreprintMicrobiology