Author

S. Lakdawala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:human· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2 Organism:rat· 2

Frequent Co-Authors

V. Le Sage· 5 shared L. Marr· 4 shared A. J. French· 3 shared A. Avery· 2 shared J. E. Jones· 2 shared K. Kormuth· 2 shared M. M. Myerburg· 2 shared M. Shephard· 2 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

V. Le Sage

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Ventilation does not affect influenza virus transmission efficiency in a ferret playpen setup

N. C. Rockey, V. Le Sage, M. Shephard, N. Vargas-Maldonado, A. J. French, S. Walter, L. M. Ferreri, K. E. Holmes, D. VanInsberghe, H. Clack, A. J. Prussin, A. C. Lowen, L. Marr, S. Lakdawala

This study shows that ventilation rates do not affect influenza virus transmission efficiency in a ferret playpen setup with close-range interactions and fomites.

bioRxiv · Dec 26, 2023 · PreprintMicrobiology

Influenza infected macrophages release viral ribonucleoproteins that shape the local host response

S. Fritzlar, S. Lakdawala, J. A. Roberts, L. J. M. Coin, Y.-M. Deng, J. Moselen, V. Le Sage, J. Mackenzie, L. Labzin, A. G. Brooks, P. Reading, S. Londrigan

This study shows that influenza-infected macrophages release viral ribonucleoproteins (vRNPs) that trigger inflammatory responses in uninfected cells through the RIG-I/MDA5 pathway.

bioRxiv · Dec 4, 2023 · PreprintMicrobiology

Seasonal influenza viruses decay more rapidly at intermediate humidity in droplets containing saliva compared to respiratory mucus

N. C. Rockey, V. M. Le Sage, L. Marr, S. Lakdawala

This study shows that influenza viruses in saliva droplets lose infectivity faster than in respiratory mucus at intermediate humidity, suggesting oral cavity expulsions may contribute to transmission.

bioRxiv · Jul 11, 2023Microbiology

Variability in donor lung culture and relative humidity impact the stability of 2009 pandemic H1N1 influenza virus on nonporous surfaces

Z. Qian, D. H. Morris, A. Avery, K. Kormuth, L. S. M. Valerie, M. M. Myerburg, J. O. Lloyd-Smith, L. Marr, S. Lakdawala

This study examines how donor lung culture variability and relative humidity affect the stability of H1N1pdm09 virus on nonporous surfaces, finding that donor differences impact persistence more than surface material.

bioRxiv · Apr 17, 2023Microbiology

Detection of Influenza virus and Streptococcus pneumoniae in air sampled from co-infected ferrets and analysis of their influence on pathogen stability

A. J. French, N. Rockey, V. Le Sage, K. Mueller Brown, M. Shephard, S. Frizzell, M. M. Myerburg, N. L. Hiller, S. Lakdawala

This study detects influenza virus and Streptococcus pneumoniae in air samples from co-infected ferrets and assesses their impact on pathogen stability in expelled droplets.

bioRxiv · Feb 24, 2023 · PreprintMicrobiology

Environmental Stability of Enveloped Viruses is Impacted by the Initial Volume and Evaporation Kinetics of Droplets

S. Lakdawala, A. J. French, A. K. Longest, J. Pan, P. Vikesland, N. K. Duggal, L. Marr

This study examines how droplet volume and humidity affect the environmental stability of enveloped viruses, finding that virus decay is more similar at higher humidity and in smaller droplets.

bioRxiv · Jul 26, 2022Microbiology

Host origin is a determinant of parallel evolution between influenza virus gene segments.

J. E. Jones, S. Lakdawala

This study shows that host origin, not geographic lineage, drives parallel evolution in avian H9 influenza virus gene segments.

bioRxiv · Feb 7, 2022 · PreprintEvolutionary Biology

Pre-existing immunity provides a barrier to airborne transmission of influenza viruses

S. Lakdawala, V. Le Sage, J. Jones, K. Kormuth, W. Fitzsimmons, E. Nturibi, G. Padovani, C. Arevalo, A. French, A. Avery, R. Manivanh, E. E. McGrady, A. Bhagwat, A. S. Lauring, S. E. Hensley

The paper shows that pre-existing non-neutralizing immunity in ferrets blocks airborne transmission of seasonal influenza viruses.

PLOS Pathogens · Feb 18, 2021Peer-reviewedMicrobiology

Parallel evolution between genomic segments of seasonal human influenza viruses reveals RNA-RNA relationships

J. E. Jones, V. Le Sage, G. H. Padovani, M. Calderon, E. S. Wright, S. Lakdawala

This study identifies RNA-RNA interactions in seasonal human influenza viruses by analyzing parallel evolution between genomic segments, revealing coevolution patterns not explained by protein sequence alone.

bioRxiv · Jan 14, 2021Microbiology

The Viral Polymerase Complex Mediates the Interaction of vRNPs with Recycling Endosomes During SeV Assembly

E. Genoyer, K. Kulej, C.-t. Hung, P. A. Thibault, K. Azarm, T. Takimoto, B. A. Garcia, B. Lee, S. Lakdawala, M. D. Weitzman, C. B. Lopez

The paper identifies viral polymerase complex components L and C as mediators of vRNP interaction with Rab11a-marked recycling endosomes during SeV assembly.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology