Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export.
N. Gomez-Navarro, J. Maldutyte, K. Poljak, S.-Y. Peak-Chew, J. Orme, B. Bisnett, C. H. Lamb, M. Boyce, D. Gianni, E. A. Miller
The paper inhibits protein secretion by disrupting receptor-coat interactions, specifically targeting PCSK9 and other SURF4 clients without affecting other secreted proteins.
bioRxiv · Jan 31, 2022Cell Biology