O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations
D. T. Huynh, J. Hu, J. R. Schneider, K. N. Tsolova, E. J. Soderblom, A. J. Watson, J.-T. A. Chi, C. S. Evans, M. Boyce
This study shows that O-GlcNAcylation regulates NF-L assembly and function, and CMT mutations disrupt this process, linking glycosylation defects to neurodegeneration.
bioRxiv · Feb 22, 2023Cell Biology