Cell BiologybioRxiv
Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export.
N. Gomez-Navarro, J. Maldutyte, K. Poljak…·E. A. Miller
The paper inhibits protein secretion by disrupting receptor-coat interactions, specifically targeting PCSK9 and other SURF4 clients without affecting other secreted proteins.
DOI 10.1073/pnas.2202080119