Collagen receptor GPVI-mediated platelet activation and pro-coagulant activity aggravates inflammation and aortic wall remodelling in abdominal aortic aneurysm
T. Feige, A. Bosbach, K. J. Krott, J. Mulorz, M. Chatterjee, J. Ortscheid, E. Krueger, I. Krueger, W. Ibing, M. Grandoch, M. U. Wagenhaeuser, H. Schelzig, M. Elvers
This study shows that GPVI-mediated platelet activation worsens AAA by promoting inflammation and aortic wall remodeling, suggesting GPVI as a therapeutic target.
bioRxiv · Nov 20, 2023 · PreprintCell Biology