BiochemistrybioRxiv
Molecular Basis for the Evolved Instability of a Human G-Protein Coupled Receptor
L. M. Chamness, N. B. Zelt, C. P. Kuntz…·J. P. Schlebach
The paper identifies a C-terminal truncation and increased TM domain polarity in GnRHR as evolutionary adaptations that reduce receptor stability and activity.
DOI 10.1016/j.celrep.2021.110046