LDL-Binding IL-10 Reduces Vascular Inflammation in Atherosclerotic Mice
L. R. Volpatti, S. Norton de Matos, G. Borjas, J. Reda, E. A. Watkins, Z. Zhou, M. Nguyen, A. Solanki, Y. Fang, J. A. Hubbell
This paper develops a targeted IL-10 therapy by fusing it with an LDL-binding antibody fragment, showing reduced vascular inflammation in atherosclerotic mice.
bioRxiv · Mar 4, 2024Bioengineering