Y. Fang

G-quadruplexes are a source of vulnerability in BRCA2 deficient granule cell progenitors and medulloblastoma

This study identifies G-quadruplexes as a source of genome instability in BRCA2-deficient granule cell progenitors and medulloblastoma, suggesting PIF1 helicase as a therapeutic target.

Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses

The paper shows apoptotic caspases cleave DRP1 to induce mitochondrial fusion and enhance anti-viral immunity during viral infections.

Genome-resolved year-round dynamics reveal a broad range of giant virus microdiversity

This study analyzes giant virus dynamics using metagenomic data, revealing year-round recovery and distinct population dynamics linked to microdiversity and niche breadth.

Digital Immunoassay for Rapid Detection of SARS-CoV-2 Infection in a Broad Spectrum of Animals

This paper develops a digital immunoassay for rapid detection of SARS-CoV-2 antibodies in multiple animal species with high sensitivity and specificity.

Mechanosensitive FHL2 tunes endothelial function

This study identifies FHL2 as a mechanosensitive protein that drives endothelial dysfunction under athero-prone flow conditions by modulating adherens junctions and Rho-ROCK signaling.

Poxvirus A52 is a host range factor for modified vaccinia virus Ankara (MVA) and promotes viral replication by disturbing the formation of autolysosomes

This study identifies poxvirus protein A52 as a host range factor that disrupts autolysosome formation to promote viral replication in MVA.

Pencil Beam Based X-ray Luminescence Computed Tomography Imaging of Deep TargetsThree-dimensionally and Quantitatively

This paper introduces weighted filtered back projection (wFBP) for XLCT, enabling 3D quantitative imaging of deep targets with high spatial resolution and improved accuracy.

Spatiotemporal dynamics revealed the dark water community of giant virus from a deep freshwater lake

This study uses long-read metagenomics to reconstruct giant virus genomes from a freshwater lake, revealing new species and ecological roles in different water depths.

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Sediment-associated processes account for most of the spatial variation in stream ecosystem respiration in the Yakima River basin

The paper evaluates a process-based model for predicting stream ecosystem respiration (ERtot) in the Yakima River basin and finds it fails to explain spatial variation, highlighting the importance of sediment-associated respiration and other factors.

The molecular basis of pine wilt disease resistance in Pinus massoniana

This study identifies three molecular resistance strategies in Pinus massoniana cultivars against pine wood nematodes using transcriptome and metabolome profiling.

LDL-Binding IL-10 Reduces Vascular Inflammation in Atherosclerotic Mice

This paper develops a targeted IL-10 therapy by fusing it with an LDL-binding antibody fragment, showing reduced vascular inflammation in atherosclerotic mice.

High immigration rates critical for establishing emigration-driven diversity in microbial communities

The paper investigates how microbial dispersal affects community diversity under competition, finding that high immigration rates enhance diversity through emigration.

Architecture of the spinach plastid-encoded RNA polymerase

This study presents the cryo-EM structure of the spinach plastid-encoded RNA polymerase complex, revealing its composition and spatial arrangement of subunits and associated proteins.

IOBR2: Multidimensional Decoding Tumor Microenvironment for Immuno-Oncology Research

IOBR2 is a tool for analyzing tumor microenvironment using multi-omics data, offering modules for preprocessing, estimation, interaction analysis, and visualization.

CDC5L surveils cellular stress responses and stress granule formation through transcriptional repression

This study identifies CDC5L as a transcriptional repressor that prevents spontaneous stress granule formation by suppressing PERK-eIF2 signaling.

The trade-off between individual metabolic specialization and versatility determines the metabolic efficiency of microbial communities

This study shows that microbial communities with metabolic redundancy outperform both specialized and division-of-labor systems in naphthalene degradation.

Phosphorylated transcription factor PuHB40 is involved in ROS-dependent anthocyanin biosynthesis in pear exposed to high-light stress

This study identifies PuHB40 as a phosphorylation-regulated transcription factor that mediates ROS-dependent anthocyanin biosynthesis in pear under high-light stress.

Streamlined DNA template preparation and co-transcriptional 5' capped RNA synthesis enabled by solid-phase catalysis

This paper demonstrates a solid-phase enzymatic platform for streamlined mRNA synthesis, enabling efficient and continuous production of capped RNA without purification steps.

Multi-pass, single-molecule nanopore reading of long protein strands with single-amino acid sensitivity

This paper demonstrates a method to sequence long protein strands with single-amino-acid sensitivity using nanopore sensors and ClpX unfoldase, enabling accurate protein barcode sequencing and analysis of folded protein domains.

The SARS-CoV-2 Spike is a virulence determinant and plays a major role on the attenuated phenotype of Omicron virus in a feline model of infection

This study shows the Omicron BA.1 Spike protein reduces SARS-CoV-2 virulence in a feline model by impairing viral spread and causing less severe disease.

Duplication and neofunctionalization of a horizontally-transferred xyloglucanase as a facet of the red queen co-evolutionary dynamic

The paper investigates the duplication and neofunctionalization of a horizontally-transferred xyloglucanase gene in oomycetes, showing how these variants contribute to plant pathogenesis and host-pathogen co-evolution.

Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells

The paper shows that age-related STAT3 signaling impairment in neonatal bronchial epithelial cells increases RSV infection severity, while SARS-CoV-2 is unaffected by age.

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

This study shows that p63 regulates the balance between squamous and neuroendocrine cell fates in esophageal development and cancer by modulating epigenetic mechanisms.

Fibroblast growth factor-21 induces skeletal muscle atrophy and increases plasma amino acids in female mice: a potential role for glucocorticoids

This study shows FGF21 induces skeletal muscle atrophy and increases plasma amino acids in female mice, likely via glucocorticoid signaling and HPA axis activation.

Anoctamin-1 is induced by TGF-beta and contributes to lung myofibroblast differentiation

This study shows TGF-beta induces ANO1 in lung fibroblasts, which increases intracellular chloride and activates WNK1 to promote myofibroblast differentiation and fibrosis.

Comparative analysis of drug-like EP300/CREBBP acetyltransferase inhibitors

This study compares the biochemical and biological potencies of three EP300/CREBBP acetyltransferase inhibitors and demonstrates their utility in investigating epigenetic mechanisms.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

Duckweed evolution: from land back to water

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

A Novel ARNT-Dependent HIF-2α Signaling as a Protective Mechanism for Cardiac Microvascular Barrier Integrity and Heart Function Post-Myocardial Infarction

This study identifies HIF2/ARNT as a protective axis in cardiac endothelial cells post-MI, preventing vascular leakage and inflammation through suppression of IL6.