Computationally-guided design and affinity improvement of a protein binder targeting a specific site on HER2
T. Y. Kim, J. S. Cha, H. Kim, Y. Choi, H.-S. Cho, H.-S. Kim
The paper computationally designs and improves a protein binder targeting HER2 domain IV, achieving a two-orders-of-magnitude increase in binding affinity through iterative computational and experimental feedback.
bioRxiv · Nov 9, 2020Biochemistry