Y. Choi

Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure

This paper develops SIRPα-expressing extracellular vesicles from engineered stem cells to treat acute liver failure by resolving necroptosis and promoting liver regeneration, showing reduced liver damage and improved survival in models.

Design and Evaluation of Nanoscale Materials with Programmed Responsivity towards Epigenetic Enzymes

This paper designs and evaluates nanomaterials that disassemble in response to HDAC enzymes, revealing a mechanism based on deacetylation-induced amphiphilicity reduction.

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAs

The paper identifies cancer-specific transposon-fusion RNAs across 34 cancer types and finds they are associated with tumor suppressors and oncogenes, and can activate T-cells.

The Translesion Polymerase Pol Y1 is a Constitutive Component of the B. subtilis Replication Machinery

This study compares the localization and dynamics of the TLS polymerase Pol Y1 in Bacillus subtilis with its E. coli homolog Pol IV, revealing differences in their regulation and replication machinery association.

Elucidating the role of water in collagen self assembly by isotopically modulating collagen hydration

This study investigates how water isotopes affect collagen self-assembly by comparing D2O and H2O, finding faster assembly and thinner fibrils in D2O due to reduced hydration.

Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie Bandavirus in aged ferrets

This paper develops a self-assembling ferritin nanoparticle vaccine targeting DBV Gn head region that fully protects aged ferrets from lethal DBV challenge.

Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research

The paper constructs a proteome resource, Borrelia PeptideAtlas, by integrating transcriptomic and proteomic data from multiple B. burgdorferi isolates to identify common proteins across infective strains.

Immunogenicity of COVID-19 vaccines and their effect on the HIV reservoir in older people with HIV

This study evaluates the immunogenicity of COVID-19 vaccines in older people with HIV and their impact on HIV reservoirs, finding that three doses are needed for optimal neutralizing responses but vaccines may increase HIV reservoirs in those with persistent viremia.

Embryo-specific epigenetic mechanisms reconstitute the CHH methylation landscape during Arabidopsis embryogenesis

This study identifies embryo-specific epigenetic mechanisms that reprogram CHH methylation during Arabidopsis embryogenesis, revealing distinct roles for RdDM and CMT2 pathways.

Biophysical modeling with variational autoencoders for bimodal, single-cell RNA sequencing data

The paper introduces biVI, a variational autoencoder for bimodal single-cell RNA sequencing data, which models biophysical processes to capture cell type structure and parameter values.

H2A.X mutants exhibit enhanced DNA demethylation in Arabidopsis thaliana

This study shows that H2A.X mutants in Arabidopsis thaliana exhibit reduced CG DNA methylation in endosperm, primarily in transposons and intergenic regions, suggesting H2A.X's role in maintaining methylation homeostasis.

A TMT-based quantitative proteomics approach toward α-syn PFF associated Lewy Body Dementia (LBD) using α-syn PFF-injected mouse brain tissues

This study uses TMT-based quantitative proteomics to identify proteomic changes in mouse brains injected with α-syn PFF, revealing pathways and proteins associated with LBD.

Adaptive Optical Coherent Raman Imaging of Axons through Mouse Cranial Bone

This paper demonstrates label-free vibrational imaging of myelin in mouse brains through thick cranial bones using adaptive optics-enhanced coherent Raman scattering microscopy.

Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone

Machine learning analysis reveals the dynamics of mode transition in dendritic cell migration

This study uses machine learning to analyze dendritic cell migration patterns and identifies three distinct motility modes and their transitions during maturation.

Helminth egg derivatives as pro-regenerative immunotherapies

This study develops a regenerative immunotherapy using helminth-derived soluble egg antigen to promote tissue repair in multiple injury models.

Immunogenicity of an Ad26-based SARS-CoV-2 Omicron Vaccine in Naïve Mice and SARS-CoV-2 Spike Pre-immune Hamsters

This study evaluates an Ad26-based Omicron spike vaccine in mice and pre-immune hamsters, showing it induces neutralizing antibodies against Omicron and Delta variants.

Amplification of Olfactory Signals by Anoctamin 9 is Essential for Mammalian Olfaction: a Risk Factor for the Covid-19-associated Anosmia

This study identifies Anoctamin 9 as essential for mammalian olfaction, showing its role in amplifying olfactory signals and linking its downregulation to Covid-19-associated anosmia.

Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal anti-tumor immunity

Immune checkpoint blockade therapy promotes gut microbiota translocation into secondary lymphoid organs, enhancing extraintestinal anti-tumor immunity.

Patient induced pluripotent stem cell-derived hepatostellate organoids establish a basis for liver pathologies in telomeropathies

The paper uses patient-derived iPS cells to model liver pathologies in telomeropathies and identifies AKT suppression as a potential therapeutic target.

Nonadditive gene expression is correlated with nonadditive phenotypic expression in interspecific triploid hybrids of willow (Salix spp.)

This study shows nonadditive gene expression correlates with nonadditive phenotypic expression in willow triploid hybrids, with dominance effects linked to biomass yield and starch metabolism.

Exhausted mature dendritic cells exhibit a slower and less persistent random motility but retain chemotaxis against CCL19

This study shows that exhausted mature dendritic cells (xmDCs) move more slowly and less persistently than active matured DCs and immature DCs, but retain CCR7-dependent chemotaxis to CCL19.

Insertive vaginal sex has a profound impact on the penile immune correlates of HIV susceptibility

This study examines how insertive vaginal sex affects penile immune markers linked to HIV susceptibility, finding rapid increases in cytokines like IL-8 and MIG post-sex, influenced by partner's vaginal secretions.

Single-cell RNA-sequencing of Nicotiana attenuata petal cells reveals the entire biosynthetic pathway of a floral scent

The paper uses scRNA-seq to identify cell populations in Nicotiana attenuata petals and uncover the biosynthetic pathway of benzylacetone.

Extracellular vesicles induce aggressive phenotype of luminal breast cancer cells by PKM2 phosphorylation

This study shows that extracellular vesicles from highly glycolytic breast cancer cells induce an aggressive phenotype in low glycolytic luminal breast cancer cells via PKM2 phosphorylation.

Ad26.COV2.S-elicited immunity protects against G614 spike variant SARS-CoV-2 infection in Syrian hamsters and does not enhance respiratory disease in challenged animals with breakthrough infection after sub-optimal vaccine dosing

This study shows that a single dose of Ad26.COV2.S vaccine protects Syrian hamsters from G614 SARS-CoV-2 infection and prevents VAERD even with suboptimal immunity.

Immunogenicity and protective efficacy of one- and two-dose regimens of the Ad26.COV2.S COVID-19 vaccine candidate in adult and aged rhesus macaques

This study evaluates one- and two-dose regimens of the Ad26.COV2.S vaccine in rhesus macaques, showing higher antibody responses with two doses and protection against SARS-CoV-2 in aged animals.

Computationally-guided design and affinity improvement of a protein binder targeting a specific site on HER2

The paper computationally designs and improves a protein binder targeting HER2 domain IV, achieving a two-orders-of-magnitude increase in binding affinity through iterative computational and experimental feedback.

The SARS-CoV-2 RNA interactome

This study identifies 109 host factors interacting with SARS-CoV-2 RNA and reveals their roles in antiviral or proviral functions through RNP capture and knockdown experiments.

Two-target quantitative PCR to predict library composition for shallow shotgun sequencing

The paper develops a two-target qPCR assay to predict human-to-microbe ratios in samples, enabling better planning of shotgun sequencing experiments.