Genome-wide CRISPR and small-molecule screens uncover targetable dependencies in ATRT
D. J. Merk, S. Hirsch, F. Tsiami, B. Walter, L. A. Haeusser, S. Babaei, J. Admar, N. Casadei, C. Roggia, M. Spohn, J. Schittenhelm, S. Singer, U. Schueller, F. Piccioni, N. S. Persky, , G. Tabatabai
This study identifies targetable genetic dependencies in ATRT using CRISPR and small-molecule screens, revealing CDK4/6 inhibitors as potent therapeutic options.
bioRxiv · Dec 9, 2020 · PreprintCancer Biology